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Background: Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants known for their efficacy and tolerability. However, their use is associated with serious safety concerns, particularly the Black Box Warning (BBW) highlighting increased risks of suicidal ideation in children, adolescents, and young adults. While these risks are well-documented, the level of awareness and preparedness among pharmacy students—future frontline healthcare providers—to counsel patients on these warnings remains unclear. Objective: This study aimed to evaluate pharmacy students’ knowledge and attitudes toward SSRIs and their associated BBW, focusing on the students' understanding of risks, contraindications, monitoring requirements, and the importance of patient education. Methods: A cross-sectional survey was conducted among 53 pharmacy students using a structured questionnaire. The instrument covered demographic information, familiarity with BBWs, knowledge-based true/false questions about SSRIs, and opinion-based statements rated on a 4-point Likert scale. Descriptive and inferential statistics were used to analyze the data using SPSS. Results: The average knowledge score was 70.8%, indicating a moderate understanding of SSRI-related safety. While 77.4% correctly identified the clinical indications of SSRIs, only 66.0% were aware of the BBW's emphasis on suicidality in young patients. Students showed high agreement (85–95%) with recommended clinical practices, such as the need for explicit risk warnings, closer monitoring, and patient counseling. Statistically significant associations were found between students’ academic backgrounds and their knowledge and attitudes. Those with health science majors or more pharmacy experience scored higher and demonstrated stronger alignment with safety practices. Conclusions: Despite general awareness, substantial gaps remain in pharmacy students’ detailed understanding of BBW content and safety monitoring related to SSRIs. These findings underscore the need to strengthen pharmacy curricula with focused education on high-risk medications and patient safety practices.

The advancement of analytical methodology, a better knowledge of the stability of active ingredients (API) and drug products (DP), and information regarding degradation pathways and degradation products are all made possible by forced degradation studies. This document describes the parameters of force degradation experiments, including the goals of ensuring drug stability, the time required to conduct drug degradation studies, and the factors—such as light, pH, and oxygen—that effect drug deterioration. The significance of the stability-indicating method and the connection between stability data and forced degradation investigations are emphasized in the study. Studying force degradation is crucial because it gives you the information and insight you need to create an analytical technique that indicates stability. The specifications and shelf life of a drug substance or drug product are established in part by this investigation.

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