Depression is a major mental health disorder affecting millions globally. The increasing side
effects and limitations of conventional antidepressant medications ha ve prompted interest in
alternative therapies, particularly those derived from medicinal plants. This review compiles
findings from 32 plants, analyzing their antidepressant properties, plant parts used, extraction
solvents, mechanisms of action, and exper imental outcomes. Notable herbs such as Crocus
sativus , Curcuma longa , Hypericum perforatum , and Bacopa monniera showed comparable
or synergistic effects with standard antidepressants like fluoxetine. Extracts, often
methanolic, ethanolic, or aqueous, targ eted neurotransmitter systems (serotonin, dopamine,
noradrenaline) and exhibited monoamine oxidase inhibition, antioxidative effects, and
modulation of neurotrophic factors. These findings support the therapeutic potential of plant
based treatments for dep ressive disorders.